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Accutane is the former prescription drug brand name for isotretinoin, a vitamin A derivative often used to treat severe acne (isotretinoin is now sold under the generic names Zenatane, Absorica, Myorisan, Claravis, and Amnesteem instead)

Warnings: The use of cyanocobalamin is warned in patients with early Lebers disease as there have been reports of severe and swift optic atrophy with its administration

Within each fold, models were fitted on four subsets and evaluated on the held-out subset, yielding mean metrics across folds: Accuracy (fraction correctly classified), AUROC, AUPRC, Specificity (true negative rate), Precision(proportion of positive predictions that are correct), and Recall (proportion of actual positives that are correctly identified)