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The satellite-cell hypothesis The central hypothesis around MGF is that its transient early expression after muscle injury serves to activate quiescent satellite cells the resident muscle stem cells pushing them into proliferation while delaying their terminal differentiation, thereby expanding the pool of myogenic precursors available for repair before the later, IGF-1Ea-driven phase completes the regeneration

In contrast, inhibition of TREM1 has also demonstrated protective effects in mouse models of neurodegenerative diseases (Wilson et al., 2024)

HRP-labeled rabbit anti-rat IgG (ab6734) was purchased from Abcam (Cambridge, MA, USA)

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