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The chronic oxidative stress seen in Long COVID and ME/CFS damages the endothelial cells lining the blood vessels, worsening this vascular dysfunction and perpetuating the cycle of poor circulation and autonomic misfiring

Chronic sleep deprivation can lead to higher oxidative stress, which uses up your antioxidant reserves

Only one subject had a milder presentation with slowing of development starting at the age of 6 months

To also evaluate the sample processing quality of streamlined workflow, we compared it to our previous stateoftheart protocol for the processing of deparaffinized FFPE tissue in a 96well format (Coscia et al , 2020) by processing a subset of liver tissues from our cohort both on the same LC and MS instruments