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11, eadq7307 (2025), Abstract Endogenous SLPI contributes to the regulation of inflammatory responses in peritoneal macrophages by modulating MMP-9 production: Tyshchenko, M., Pocau, N., et al

In a study involving patients with NAFLD (non-alcoholic fatty liver disease) given 300 mg of glutathione daily for 4 months, there were significant reductions in ALT (a liver enzyme that is elevated with liver damage), triglycerides, and ferritin

The mechanism is based on a reduction of Th17 differentiation of CD4 + T cells by inhibiting GLS1, glycolysis, and CD4 + T-cell differentiation in vitro by reducing the level of HIF1 protein, a key metabolic sensor in Th17 cells (9) ( Table 1 )

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