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Preclinical studies indicate that simultaneous or near-simultaneous administration produces maximal synergy, with synergistic effects declining as the interval between administrations exceeds 15-30 minutes

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PEGylation A common approach for muco-penetrating particles or muco-inert particles involves coating them with brush-like polyethylene glycol (PEG), whose electric neutrality, high flexibility and remarkable hydrophilicity reduce chain entanglement and shield the hydrophobic core 148,149,150,151,152,153,154,155,156,157,158,159,160

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