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The process of pigmentation is mediated by melanin, a complex polymer derived from the amino acid tyrosine, and pigment cells are called melanocytes

J Cardiovasc.Pharmacol 2007;50(2):168-175

doi: 10.1155/2015/340812 38 RanieriA.DUrsoG.NaliC.LorenziniG.SoldatiniG

Hypoxia induces XBP1 mRNA expression and splicing in a HIF-1 independent manner, resulting in increased levels of activated XBP1 protein, and XBP1 loss severely inhibits tumour growth due to a reduced capacity for tumour cells to survive in hypoxic microenvironments in vitro and in vivo 79,80