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Natural product fargesin interferes with H3 histone lactylation via targeting PKM2 to inhibit non-small cell lung cancer tumorigenesis

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The criteria for exclusion were as follows: rats with signs of external ear disorders (impacted earwax, tumors, external acoustic meatus edema, and hyperemia), rats with middle ear disorders (opacification, hyperemia, and bulging or perforations of the tympanic membrane), and rats without DPOAE in any of the studied frequencies (18 kHz)