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In addition, FASN inactivation results in impaired eNOS palmitoylation, increased vascular permeability and inflammation, and defective angiogenesis, further reinforcing its regulatory role in EC health [108]

First, we assessed protein expression in Be(2)-C cells treated with either MitoQ IC50, DPI IC50, vin IC50 or the double and triple drug combinations, versus control ( Supplementary Figures S3 - S6

For instance, Ferrostatin-1, a specific ferroptosis inhibitor, has demonstrated significant attenuation of adriamycin-induced cardiac injury and heart failure in murine models, suggesting a promising drug target for CAD treatment

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