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The flux of methionine through the transmethylation and transsulfuration pathways in liver and other tissues is also significantly higher in the Ames mice when compared to their wild-type controls [25]

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liewska K, Cukrowska B, Smulikowska S, Cielecka-Kuszyk J (2019) The effect of probiotic supplementation on performance and the histopathological changes in liver and kidneys in broiler chickens fed diets with aflatoxin B1

Subsequent efforts to identify the enzyme responsible for cGAMP production led to the characterization of cyclic GMP-AMP synthase (cGAS), a cytosolic DNA sensor that directly binds double-stranded DNA and catalyzes cGAMP synthesis upon activation (Sun et al., 2013)