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Elevated MDH activity under hypoxia has been associated with the lungs (87), renal (88), and pancreatic cancers (89), as well as osteoclastogenesis (90), neurodevelopmental delay, senescence, and other pathologies (80, 91)

This process is regulated by the JNK/MTF1/FPN pathway, which constitutes a potential therapeutic target (179)

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Ommaya and colleagues showed that unconsciousness occurred more readily in adult nonhuman primates when rapid head rotations were achieved via direct blows to the head than when they were achieved via a non-head contact whiplash motion (Ommaya et al., 1973)