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Saxenda is a GLP-1 receptor agonist administered as a daily subcutaneous injection for weight management in adults with BMI 30 kg/m or 27 kg/m with comorbidities Lumps commonly result from localised inflammation, lipohypertrophy from repeated injections in the same area, or rarely from infection or improper technique Prevention requires rotating injection sites within the abdomen, thigh, or upper arm, maintaining at least 1 cm distance between consecutive injections Proper technique includes using a new needle each time, injecting at 90 degrees, and keeping the needle in skin for at least 6 seconds after injection Most lumps resolve spontaneously with site avoidance

Hu Y, Zhou Y, Yang Y et al (2022) Metformin protects against diabetes-induced cognitive dysfunction by inhibiting mitochondrial fission protein DRP1

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