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Intracellular expression of Tat alters mitochondrial functions in T cells: a potential mechanism to understand mitochondrial damage during HIV-1 replication

Interestingly, GAS7-knockout cells exhibited defects in lamellipodia formation, indicating that GAS7 is part of the shared mechanisms between phagocytosis and lamellipodia formation, including actin dynamics regulation 41,43

For instance, a 2024 translational study found that long-term metformin administration in a transgenic AD mouse model elevated soluble A oligomers and the plaque burden, in conjunction with higher BACE1 expression levels [181]