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Despite these diverse origins, such as metabolic dysfunction, immune attack, toxic exposure or vascular injury, the pathophysiological mechanisms involved tend to converge on a common pathway characterized by inflammation, fibrosis, nephron loss and eventual functional failure [15,16,17,18]

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As shown in Figure 1, the number of publications in this area is increasing each year, highlighting the relevance of such a review

The PVDF membrane that contained the protein was blocked with 1% (w/v) skim milk in Tris-buffered saline with Tween-20 (TBST) and then incubated overnight with primary antibodies against NF-B (1:500), Akt (1:500), p-Akt (1:1000) (Abcam, UK), P-p65 (1:1000), P38 (1:1000), and p-P38 (1:800) (Cell Signaling, MA, USA) at 4C