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This dose increases serum levels of -hydroxybutyrate by as much as 4 mM, similar to the level seen after two weeks of starvation, four times greater than what is seen after several weeks of a ketogenic diet, and up to 40 times higher than what is seen following an overnight fast, with levels returning to baseline after approximately 4 h [25]

Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator

A., Faiyaz, A., Khan, O

However, the clinical use of natural agonists is limited by poor bioavailability, while synthetic agents like thiazolidinediones are associated with adverse effects, including fluid retention, weight gain, and bone loss