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Limited long-term human data prevents definitive safety conclusions, but decades of research suggest low risk with proper use

Oxygen toxicity protecting enzymes in Parkinson's disease

The ligand occupies the ATP binding site of c-Met, competes with ATP by forming hydrogen bonds with Met 1160, and binds with Asp 1222 in the active region of c-Met to form hydrogen bonds, thus producing strong kinase inhibitory activity (Fig