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Targeting lipid metabolism has the potential anti-tumor activity in preclinical studies (Orabi et al., 2021)

Farnesyltransferase inhibitors reverse the proliferative phenotype in Nf1 -deficient mouse cells, and can reverse spatial learning impairments in a mouse model of NF1 , by decreasing RAS levels.6 These observations have prompted investigations into the use of farnesyltransferase inhibitors for the treatment of NF-1-related complications, such as rapidly growing plexiform neurofibromas

Nevadensin relieves food allergic responses and passive cutaneous anaphylaxis in mice through inhibiting the expression of c-Kit receptors

Quercetin: A promising therapy for diabetic encephalopathy through inhibition of hippocampal ferroptosis