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ROK 1977

Indeed, loss of glutathione peroxidase 4, a oxidation-resistant selenoprotein that utilizes GSH, leads to lipid peroxidation and subsequent ferroptosis, which is also found in epilepsy models ( The NADPH oxidase (NOX) family of enzymes is another relevant major source of ROS in the context of epilepsy as evidenced by activation of NOX2 by kainate-induced SE (Patel et al., 2005)

Promising biomarkers include syn aggregates in CSF and blood [28]

Morita K, Wang F, Patel K, Bueso-Ramos C, IssaGC, Song X, Zhang J, Tippen S, Thornton R, Coyle M, Little L, Gumbs C, Ravandi F, Kadia T, Daver N, Konopleva M, Andreeff M , Cortes JE, Garcia-Manero G, Jabbour EJ, Futreal A, Kantarjian HM, Takahashi