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treatment of the adipocytes with the NNMT inhibitor 5-amino-1MQ resulted in a concentration-dependent increase in the NAD+ levels with concentrations in the range of 1-60 M resulting in 1.2-1.6-fold increase in NAD+ levels relative to control adipocytes

AOD-9604 and semaglutide work through entirely different mechanisms, and understanding the gap between them clarifies something important about how the peptide-for-fat-loss space is often misrepresented

Most side effects are mild, localized, and transient

Further analysis suggested that the peptide may have increased the ratio of Bcl-2/Bax, and potentially decreased cleaved caspase-3 and PARP levels, two markers of cell death