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First, the imbalance in ER homeostasis, as multifunctional organelle, caused disturbance of calcium homeostasis, glucose deprivation, increasing of ROS formation and oxidative stress induction [45]

Certain nanomaterials, including metal and metal oxide nanoparticles as well as biopolymer-based nanostructures, can disrupt microbial cell membranes, generate reactive oxygen species, or interfere with cellular metabolic processes (192)

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