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Furthermore, during COPD progression, elevated levels of pulmonary inflammation and oxidative stress markers can extend beyond locally confined regions, triggering systemic inflammation and causing brain damage [352, 353]

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*Correspondence: Dongxia Yang, [email protected]

Guided by this observation, we administered daily intraperitoneal injections of saline or uridine (1, 5, 10, or 20 mg/mL in saline) to young (68 weeks) and aged (4856 weeks) female mice for ten consecutive days (Fig