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Dietary fibers could be fermented by some species of gut microbiota and produce SCFAs, which provide energy to intestinal epithelium cells and strengthen the intestinal barrier, preventing inflammation induced by LPS (Seethaler et al., 2022)

Pharmacopoeia (2017)

37 However, unlike animal-derived exosomes, PELNs possess a complex composition, chiefly comprising lipids, proteins, nucleic acids (particularly small RNAs), carbohydrates and other small-molecule metabolites

The patient reported his mother suffered from a similar condition, and neither his nor his mothers resolved with the compression garments or modifications to diet or use of diuretics