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Studies have shown that, in the cfDNA of patients with stage III or IV CRC, the copy number of key genes related to CRC (RTK, PI3K, and Wnt) is increased, and the copy number of cfDNA changes (CNVs) is positively correlated with tumour progression

Activation (roughly weeks 1-4): once-daily dosing at the documented per-vial amount

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SetCys peptide 1 (1.32 mg, 0.881 mol, 1.2 equiv), cysteinyl peptide CILKEPVHGV-NH 2 (1.27 mg, 0.884 mol, 1.2 equiv) and peptide thioester 4 (1.14 mg, 0.735 mol, 1 equiv) were then successively dissolved in this solution (92 L) and the reaction mixture was stirred at 37 C