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In the CNS, MeHg exposure for 3 weeks in a rodent model promoted angiotensin-induced vasoconstriction in isolated basilar arterial

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In contrast, the inhibition of SIRT1 significantly diminished the protective effects of melatonin, suggesting that melatonin plays a crucial role in maintaining mitochondrial function to suppress oxidative stress by modulating the level of SIRT1 in OA progression (137)