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Although it has been suggested that further clinical trials with a patient placebo-controlled arm are required to truly confirm the efficacy of this gene therapy, this can be challenging in rare diseases like LHON

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Sometimes people with metabolic acidosis will: Feel tired Not feel hungry (loss of appetite) Feel changes in heartbeat Have trouble thinking clearly Your healthcare provider should do a blood test to measure the level of acid in your blood before and during your treatment with Topiramate