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While the methotrexate loading content within -cyclodextrin-based metalorganic framework-1 and -cyclodextrin-based metalorganic framework-2 were 0.689 and 1.217 g/g, respectively, furthermore, the release rate values of 5-fluorouracil were 89 and 96.4%, and about 41.5 and 82.4% were released from -cyclodextrin-based metalorganic framework-1 and -cyclodextrin-based metalorganic framework-2, respectively

Here we examine recent evidence indicating that combining percutaneous hepatic perfusion with immune-checkpoint inhibitors might improve patient outcomes, compare it with data from other trials and highlight key questions around patient selection, sequencing and mechanisms that will shape future strategies