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4.2 Statin Pravastatin, as a natural compound of statin, is conventionally applied to the treatment of primary hypercholesterolemia, type IIa and type IIb hyperlipidemia

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For BME-UV, the culture medium was a mixture of DMEM-F12 (Sigma-Aldrich, USA), RPMI-1640 (Life Technologies, USA), and NCTC-135 (Sigma-Aldrich, USA) at a ratio of 4:3:2, supplemented with 10% fetal bovine serum, lactose monohydrate (0,1%), lactalbumin enzymatic-hydrolysate (0.1%), ascorbic acid (10 mg/L), hydrocortisone (1 mg/L), L-glutathione (1.2 mM), insulin (1 mg/L), penicillin (50 IU/mL), and streptomycin (50 mg/L)

57 In the United States, Australia and New Zealand, a more conservative measurement has been established, starting at a 4-hour APAP concentration of 150 g/mL and known as the treatment line, which is intentionally set lower to account for inaccuracies in the history of APAP ingestion and inherent laboratory error in APAP measurement