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177 YangJ.ShiX.WangY.MaM.LiuH.WangJ.et al (2023)

(179) used transcriptome analysis to reveal mitochondrial shrinkage, lipid peroxidation, ROS accumulation, and increased PUFA levels in Cyp4v3 (homolog of human CYP4V2) knockout mouse RPE cells

In contrast, when cells had been pretreated with BSO before AX addition, a drastic decrease in both GSH and the GSH/GSSG ratio was observed compared to both control and AX-treated cells ( Figure 7A )

While a number of APAP overdose cases are due to suicide attempts, the availability of combination products, where the presence of APAP may not be easily recognized, has led to an increase in unintentional and chronic APAP overdose, accounting for over 50% of cases of APAP-related ALF4