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Second, we are also providing a second, modified version of this example to reflect a situation in which the severe supply chain disruption rebate reduction is granted for the same calendar quarter as the Part B rebatable biosimilar biological product is currently in shortage, and the application of the shortage reduction precedes application of the severe supply chain disruption reduction due to the timing of the shortage and submission of the rebate reduction request, illustrated as Example 2 in the table

We do not recommend self-administering or seeking frequent IV therapy without proper medical guidance, as this can pose unnecessary health risks

Administration Guidelines Injection Site: Gluteus medius is preferred for IM administration due to its large muscle mass

and the Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS) from the Japan Agency for Medical Research and Development (AMED) (Grant No