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10,11 This compositional change affects host metabolism via the gutliver axis: conjugated bile acids act as antagonists of FXR in the intestine, inhibiting the intestinal FXR-FGF15/19 signaling pathway, leading to upregulation of hepatic cholesterol 7-hydroxylase expression and accelerating the conversion of cholesterol to bile acids, but may also promote hepatic lipogenesis

We next performed a correlation analysis to assess the mechanism of gut microbiota in PSO, which showed that Escherichia-Shigella was positively correlated with serum levels of Total Bile Acids (TBA) and negatively with levels of Hemoglobin (Hb), Direct Bilirubin (DBIL), and Indirect Bilirubin (IBIL) in patients with PSO

Facial pigmentation is a common skin condition in which certain areas of the skin become darker due to excess melanin production

Reza MozafariMJohnsonCHatziantoniouSDemetzosC