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You should contact your GP if you experience: Persistent fatigue or weakness that affects daily activities Tingling, numbness, or pins and needles in your hands or feet Difficulty with balance or coordination Memory problems or difficulty concentrating Mood changes, particularly low mood or irritability A sore, red tongue or recurrent mouth ulcers Unexplained shortness of breath or palpitations These symptoms warrant investigation, which typically includes blood tests to measure B12 levels (or active B12 depending on the laboratory), full blood count to assess for anaemia, folate levels, and potentially other tests such as anti-intrinsic factor antibodies if pernicious anaemia is suspected

A 2025 review of research papers and patents by Jzwiak and colleagues examined the larger BPC-157 literature, reviewing preclinical data across cellular signaling, tissue biology, pharmacology, and other areas of scientific investigation

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Vitamin B12 deficiency is more common in older adults, vegetarians, vegans, and people with digestive disorders