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The most common reason for iron overload in patients with hematologic diseases is the administration of multiple red blood cell transfusions representing a massive excess of iron uptake with about 200 mg of iron in one unit of packed red blood cells ( Independent of red blood cell transfusions, disease-immanent factors can contribute to the iron overload phenotype

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Nutr Metab Cardiovasc Dis 20(1):7277 Ogawa D, Asanuma M, Miyazaki I, Tachibana H, Wada J, Sogawa N, Sugaya T, Kitamura S, Maeshima Y, Shikata K (2011) High glucose increases metallothionein expression in renal proximal tubular epithelial cells