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3.6.3 Mechanisms linking gut dysbiosis to PSCI 3.6.3.1 Neuroinflammation Gut dysbiosis and increased intestinal permeability following ischemic stroke (IS) have been linked to systemic endotoxemia and altered microbial metabolite signaling, potentially exacerbating neuroinflammation and injury (Zhang W

In addition to its anti-aging effects, this compound is critical in boosting the immune system

Together, this platform demonstrates that spatially controlled intracellular synthesis of PROTACs via tumor-targeted nano-assembly enhances degradation efficacy, overcomes the hook effect, and minimizes off-target toxicityproviding a robust and clinically promising strategy for precision protein degradation

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