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Briefly, there are four possible mechanisms of CRPC development: 1) Increased sensitivity of the AR to its agonists, 2) AR mutations that render the receptor responsive to alternate, non-androgen ligands, 3) ligand-independent AR activation, and 4) AR-independent mechanisms (Figure 5)

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0-120 min) is metabolized by multiple human CYP isoforms, and at the concentration of 10 M, the metabolic activities of CYP2C19 and CYP3A4 are particularly prominent [2]

The other half is knowing how and when to take them so your body can actually use what you are giving it