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The correlations between the aromatic protons at 7.9 and 3.8 ppm and the carbon signals were also investigated by heteronuclear multiple bond correlation (HMBC), and the structure of 3,5-dichloro-4-methoxybenzoic acid was confirmed (see Supplementary Figures 1721 for the NMR characterization)

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Semaglutide, by contrast, is a glucagon-like peptide-1 (GLP-1) receptor agonist that slows gastric emptying, suppresses appetite centrally via hypothalamic signalling, and modulates insulin secretion in response to glucose