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Subsequent reversible additionfragmentation chain transfer (RAFT) copolymerization of Gu, DSMA, and Hb monomers resulted in the formation of PEG-P(Gu)-P(DSMA)-P(Hb) with mPEG-CTA acting as the macroinitiator

This occurs through two mechanisms: upregulation of metallothionein MT2A to bind copper ions, and degradation of the key protein DLAT (Yang et al., 2025)