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A program without a target cannot be optimized through medicinal chemistry, cannot generate target-engagement biomarkers and cannot be de-risked for off-target liabilities

Mitochondrial Support Your mitochondria are the "power plants" of your cells

Skin barrier repair Commercial epidermal tissues EpiSkin (L'Oral Research and Innovation Center, Shanghai, China) is an in vitro reconstructed human epidermis (RHE) from normal human keratinocytes and is similar to the in vivo human epidermis

Dysfunction of intestinal epithelial cell polarity and function can trigger potent inflammatory responses within the gut, and related to this, mice deficient in Ap1m2, a master regulator of intestinal epithelial cell polarization, demonstrate chronic colitis