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The pathogenesis of IBD is not fully understood but involves complex interactions among genetic predisposition, immune dysregulation, environmental factors, and intestinal microbiota changes

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Overall, mast cells have 50 200 granules in the cytoplasm of the cell, storing histamine, heparin, tryptase, cytokines, etc.[ref] The image below shows mast cell (stained purple) degranulation under a microscope.[ref] Allergies: Activating mast cells by Type 1 hypersensitivity In addition to reacting to antigens on pathogens, such as bacteria, the IgE can also be primed to link with antigens on proteins that are not pathogens, referred to as allergens

Peripheral nerves may be damaged by metabolic insults, immune-mediated mechanisms, toxic exposures, hereditary defects, compressive/entrapment forces, ischemia, infiltration, or infection