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At a median follow-up of 40.9 months, acalabrutinib demonstrated non-inferiority to ibrutinib in terms of efficacy and was associated with lower rates of cardiovascular (hypertension and atrial fibrillation) and non-cardiac events (diarrhea, myalgia/arthralgia and bleeding), suggesting that greater BTK selectivity may reduce off-target effects, resulting in an improved clinical safety profile

The reduced anabolism and increased catabolism can be simultaneously driven by chronic inflammatory responses, oxidative stress, and aberrant signaling pathways

Noguchi K, Matsuzaki T, Shiroma N, Ojiri Y, Sakanashi M