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Description

Vitamin C is required for the hydroxylation step that converts proline to hydroxyproline

Choi, J

deficiency can cause harm to fetus (neurodevelopment issues)

Furthermore, GPX4 expression is regulated by multiple transcription factors, such as SP1 (Sp1 transcription factor) and TFAP2A/AP2 (transcription factor AP-2 alpha), in specific cells or conditions [9] (Figure 4A)