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Description

Abstract Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is a master regulator of oncogenic signaling, uniquely catalyzing the isomerization of phosphorylated Ser/Thr-Pro motifs to drive malignant transformation, proliferation, and metastasis

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In the IVD groups injected with allogenic GFP ve fibroblasts, we found a mixed population of autologous NP cells that were GFP +ve and FSP1 ve as well as GFP +ve and FSP1 +ve NP cells that had differentiated towards a fibrotic phenotype