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It is required for mitochondrial energy metabolism, normal nervous system function, red blood cell development and maturation, DNA synthesis and the methylation cycle, and has antioxidant effects at the cellular level

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105 Cardiac IGF1R overexpression induced physiological cardiac hypertrophy in mice, which was however blunted by cardiomyocyte-specific co-expression of a dominant negative PI3K(dnPI3K) p110 mutant

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In studies conducted by the National Toxicology Program, fertility assessments with acetaminophen have been completed in Swiss CD-1 mice via a continuous breeding study

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