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They wrote: "The VETPROOF, reported here, suggests that enalapril treatment provides a modest benefit in delaying onset of CHF, whereas the first and larger of these studies, the SVEP trial, does not." The VETPROOF authors further acknowledged the importance of SVEP's 229 cavaliers versus their multi-breed enrollment with only ten cavaliers

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5 mol treated for 24 h] exhibited protective effects against LPS-induced microglia inflammation and increased the expression of antioxidant proteins like glutathione in human neuronal (SH-SY5Y) cells (70)

However, both ROS and antioxidants have dual roles: ROS can induce cancer cell death, and some antioxidants may paradoxically promote tumour growth by reducing high levels of naturally occurring ROS in cancer cells, which would otherwise damage and kill the cells