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In other words, as a single fertilized egg cell the zygote continues to divide, the resulting daughter cells develop into the different cell types in an organism, including neurons, muscle cells, epithelium, endothelium of blood vessels, etc., by activating some genes while inhibiting the expression of others

Jie C, Han Z, Tian F, Jianhui Z, Jan Krzysztof N, Rahul K et al

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(3) ROS induces DNA oxidative damage (such as formation of 8-OHdG) and lipid peroxidation (MDA increase), triggering chondrocyte apoptosis through Bax/Bcl-2 imbalance and activation of caspase-3