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Additionally, mechanistic studies further demonstrated that KD modulates inflammatory signaling pathways in EAE models, including reducing NF-B activation and decreasing NLRP3 inflammasome activity, alongside improvements in motor outcomes [116]

Patients on methotrexate and acitretin should be advised to avoid alcohol and maintain a healthy weight, as NAFLD is a common comorbidity in psoriasis patients, exacerbating liver dysfunction (Balak et al

Animal models can be further used to explore the role of prebiotics and probiotics on cognition and behavior, including changes in depression, anxiety, and stress associated with changes in immune markers, hippocampal synaptic efficacy, and tryptophan metabolism (376, 387)

& Collins, M