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At the cellular level, glutathione functions as a cofactor for antioxidant enzymes like glutathione peroxidase and glutathione-S-transferase, which neutralize reactive oxygen species and support phase-II detoxification pathways

Importantly, low Se levels in pregnant women affect fetal growth and augment the risk of delivering a small-for-gestational age infant by reducing placental antioxidant defense, while low Se in the third trimester is thought to indicate increased demands by the placenta, an issue which requires further confirmation

10.1038/s41374-022-00737-3 77 XuS.WuB.ZhongB.LinL.DingY.JinX.et al (2021)

Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss