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Lidocaine undergoes extensive first-pass hepatic metabolism, which limits its use to IV administration (26)

Nano-sized assemblies made of amphiphilic iodinated hyaluronic acid (HA-TIBA) were developed for cancer diagnosis and therapy, enabling tumor-specific delivery of DOX while demonstrating enhanced cellular uptake and antitumor effectiveness in CD44-positive SCC7 cells via HA-CD44 receptor interactions