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Hypothyroidism refers to a state of diminished production of thyroid hormones leading to clinical manifestations of thyroid insufficiency and can occur with or without goiter, a functional hypertrophy of the gland in response to suppressed hormone production and elevated serum thyroid stimulating hormone (TSH, also known as thyrotropin) concentrations

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However, during cancer progression, the accumulation of inducible nitric oxide synthase positive (iNOS+) and CD11b+Gr1+ myeloid cells in the peritumoral region suppresses the contraction of tumor-draining collecting lymphatic vessels (117) ( Figure 1 ), which might diminish tumor antigen transportation and DC trafficking to the TDLNs, reducing the immune response (118)

Two significant checkpoints are the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway and T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3)