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Importantly, vitamin D supplementation has been shown to improve embryo quality in ICSI procedures by elevating follicular fluid and serum vitamin D levels ( Finally, folic acid has been observed to influence in vitro oocyte maturation and gene expression patterns (Gennari et al., 2021), while asiatic acid reduces oxidative stress by boosting GSH production, ATP generation, and mitochondrial membrane potential (Qi et al., 2021)

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Glutaredoxin 2 knockout increases sensitivity to oxidative stress in mouse lens epithelial cells