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Curr Pharm Des 2013 Jun 10

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Tumor angiogenesis leads to disordered internal tumor vasculature and aggravation of hypoxia, which in turn directly promotes the transcription of drug-resistance genes such as Multi-drug Resistance Protein1 ( MDR1 ), Multi-drug Resistant Associate Protein1 ( MRP1 ), and Breast Cancer Resistance Protein ( BRCP ) 4,5