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This study also found that anti-doxorubicin produced inflammation and oxidative stress in the kidneys, and that doxorubicin plus apigenin increased resistance to doxorubicin in breast cancer cells via the JAK/STAT signalling pathway (162)

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In the POUND mouse, the presence of metabolic syndrome was associated with earlier development of renal disease (12 months) and earlier mortality compared to healthy mice

Thus, the role of CD44v6 in apoptosis resistance, autophagy promotion, and consequent chemoresistance attenuation is complex, and it is involved in modulating several signaling pathways and interactions